MCP serverio.github.sanjaysgk/can-immune

Get the headline size of the CAN-IMMUNE database in one call. Returns total counts of mutations, genes, and unique mutant peptides, plus how many cell lines, tissues, and

Fetch the full record for an id returned by `search` (ChatGPT connector interface). Takes an id like 'gene:TP53' or 'cell_line:MDA-MB-231' and returns {id, title, text, ur

Get the full profile for one cancer cell line by exact name. Returns tissue of origin, cancer type, total mutations, unique mutant peptides and genes, data sources, Cellos

Get the full profile for one gene by exact symbol. Returns total mutations and how they split between cell lines vs tissues, unique mutant peptides, sample and transcript

List individual mutations in a gene (a bounded sample of rows). Each row gives the CAN-IMMUNE mutation ID (CANLIB...), the amino-acid change, the CDS change, mutation type

Look up a CACHED MHC-I binding prediction for a peptide + HLA allele. Returns the NetMHCpan result (best binding core, %Rank_EL, binder level SB/WB/NB, and neoepitope %Ran

List cancer types (histology) ranked by mutation burden. Returns each cancer type / histology with its total mutations, unique samples, and unique genes, most-mutated firs

List primary tissues ranked by mutation burden. Returns each tissue (COSMIC primary-tissue samples only, kept separate from cell lines) with its total mutations, unique sa

Search CAN-IMMUNE for genes and cell lines (ChatGPT connector interface). Returns {results: [{id, title, url}]} combining matching genes and cell lines, each with a stable

Find cancer cell lines by name, ranked by mutation burden. Returns each matching cell line with its tissue of origin, cancer type, total mutations, unique mutant peptides,

Find genes by symbol or full name, ranked by how mutated they are. Matches the gene symbol OR the full gene name (partial, case-insensitive) and returns each hit with its

Rank the most-mutated genes within one specific cell line. Answers "what is the top mutated gene in <cell line>" / "which genes are most altered in <cell line>". Returns g