Server definition

Hash: sha256:2b9bfaeb3ec73c47cbb7036eb6a516e1544d60c593740b235070e0ba7ed46269
What it is: What a remote MCP server returned when asked what it offers: 35 tools

The blob, as servednamed by its sha256

{
  "instructions": "Nullary serves negative results from drug discovery — failed compounds, terminated trials, failed CRISPR screens, antibody developability failures, and more. Search is organized by modality; every result carries provenance.",
  "tools": [
    {
      "description": "A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.",
      "inputSchema": {
        "properties": {
          "chembl_id": {
            "description": "ChEMBL molecule ID, e.g. CHEMBL941.",
            "type": "string"
          },
          "inchi_key": {
            "description": "Compound InChIKey (provide one of inchi_key, chembl_id, or pubchem_cid).",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "pubchem_cid": {
            "description": "PubChem Compound ID (CID).",
            "type": "integer"
          },
          "tier": {
            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
            "enum": [
              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "get_compound",
      "outputSchema": {
        "description": "A compound's identity plus its full negative profile across modalities and sources.",
        "properties": {
          "compound": {
            "description": "Identity: pref_name, chembl_id, inchi_key, max_phase.",
            "type": "object"
          },
          "findings": {
            "description": "Every negative finding for this molecule.",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "query_metadata": {
            "description": "Echo of the resolved query.",
            "type": "object"
          },
          "returned_count": {
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Per-modality and per-source coverage stats (honest Phase-1 numbers).",
      "inputSchema": {
        "properties": {},
        "type": "object"
      },
      "name": "get_coverage",
      "outputSchema": {
        "description": "Per-modality and per-source coverage counts.",
        "properties": {
          "by_modality": {
            "description": "Per-modality finding counts.",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "by_source_type": {
            "description": "Per-source finding counts.",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "curated_total": {
            "type": "integer"
          },
          "query_metadata": {
            "description": "Echo of the resolved query.",
            "type": "object"
          },
          "total": {
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Full provenance + detail for a single finding by id.",
      "inputSchema": {
        "properties": {
          "id": {
            "description": "finding UUID",
            "type": "string"
          }
        },
        "required": [
          "id"
        ],
        "type": "object"
      },
      "name": "get_finding_provenance",
      "outputSchema": {
        "description": "A single finding with full provenance.",
        "properties": {
          "finding": {
            "description": "The finding with source, DOI/PMID, assay context, and confidence tier.",
            "type": "object"
          },
          "query_metadata": {
            "description": "Echo of the resolved query.",
            "type": "object"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).",
      "inputSchema": {
        "properties": {
          "target": {
            "description": "gene symbol or UniProt accession (required)",
            "type": "string"
          }
        },
        "required": [
          "target"
        ],
        "type": "object"
      },
      "name": "get_model_card",
      "outputSchema": {
        "description": "Per-target Layer-1 model card: training counts and held-out scaffold-split metrics.",
        "properties": {
          "query_metadata": {
            "description": "Echo of the resolved query.",
            "type": "object"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).",
      "inputSchema": {
        "properties": {
          "target": {
            "description": "gene symbol or UniProt accession (required)",
            "type": "string"
          }
        },
        "required": [
          "target"
        ],
        "type": "object"
      },
      "name": "get_target_landscape",
      "outputSchema": {
        "description": "Target exhaustion index — distinct agents tried-and-failed, by modality and outcome.",
        "properties": {
          "by_modality": {
            "description": "Per-modality failed-agent counts.",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "by_outcome": {
            "description": "Per-outcome counts.",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "query_metadata": {
            "description": "Echo of the resolved query.",
            "type": "object"
          },
          "summary": {
            "description": "One-line natural-language summary.",
            "type": "string"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.",
      "inputSchema": {
        "properties": {},
        "type": "object"
      },
      "name": "list_models",
      "outputSchema": {
        "description": "Summary of the Layer-1 model registry: counts by family and median scaffold-split ROC-AUC.",
        "properties": {
          "query_metadata": {
            "description": "Echo of the resolved query.",
            "type": "object"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).",
      "inputSchema": {
        "properties": {
          "family": {
            "description": "target family filter (optional)",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          }
        },
        "type": "object"
      },
      "name": "list_top_targets",
      "outputSchema": {
        "description": "The most heavily-pursued targets, ranked by recorded negative findings.",
        "properties": {
          "query_metadata": {
            "description": "Echo of the resolved query.",
            "type": "object"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "ADC failures attributed to linker chemistry.",
      "inputSchema": {
        "properties": {
          "compound": {
            "description": "compound name, ChEMBL ID, or InChIKey",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "outcome": {
            "description": "outcome filter (inactive, failed_safety, terminated, …)",
            "type": "string"
          },
          "target": {
            "description": "UniProt accession or gene symbol",
            "type": "string"
          },
          "tier": {
            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
            "enum": [
              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_adc_linker_failures",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
            "type": "boolean"
          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Small-molecule ADMET failures.",
      "inputSchema": {
        "properties": {
          "compound": {
            "description": "compound name, ChEMBL ID, or InChIKey",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "outcome": {
            "description": "outcome filter (inactive, failed_safety, terminated, …)",
            "type": "string"
          },
          "target": {
            "description": "UniProt accession or gene symbol",
            "type": "string"
          },
          "tier": {
            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
            "enum": [
              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_admet_failures",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
            "type": "boolean"
          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "ADMET failures across ALL modalities.",
      "inputSchema": {
        "properties": {
          "compound": {
            "description": "compound name, ChEMBL ID, or InChIKey",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "outcome": {
            "description": "outcome filter (inactive, failed_safety, terminated, …)",
            "type": "string"
          },
          "target": {
            "description": "UniProt accession or gene symbol",
            "type": "string"
          },
          "tier": {
            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
            "enum": [
              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_admet_failures_all_modalities",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
            "type": "boolean"
          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Ancestry-specific CRISPR failures.",
      "inputSchema": {
        "properties": {
          "compound": {
            "description": "compound name, ChEMBL ID, or InChIKey",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "outcome": {
            "description": "outcome filter (inactive, failed_safety, terminated, …)",
            "type": "string"
          },
          "target": {
            "description": "UniProt accession or gene symbol",
            "type": "string"
          },
          "tier": {
            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
            "enum": [
              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_ancestry_specific_failures",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
            "type": "boolean"
          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Bispecific format/engineering failures.",
      "inputSchema": {
        "properties": {
          "compound": {
            "description": "compound name, ChEMBL ID, or InChIKey",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "outcome": {
            "description": "outcome filter (inactive, failed_safety, terminated, …)",
            "type": "string"
          },
          "target": {
            "description": "UniProt accession or gene symbol",
            "type": "string"
          },
          "tier": {
            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
            "enum": [
              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_bispecific_format_failures",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
            "type": "boolean"
          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Antibody developability failures.",
      "inputSchema": {
        "properties": {
          "compound": {
            "description": "compound name, ChEMBL ID, or InChIKey",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "outcome": {
            "description": "outcome filter (inactive, failed_safety, terminated, …)",
            "type": "string"
          },
          "target": {
            "description": "UniProt accession or gene symbol",
            "type": "string"
          },
          "tier": {
            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
            "enum": [
              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_developability_failures",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
            "type": "boolean"
          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Drug-drug interaction failures.",
      "inputSchema": {
        "properties": {
          "compound": {
            "description": "compound name, ChEMBL ID, or InChIKey",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "outcome": {
            "description": "outcome filter (inactive, failed_safety, terminated, …)",
            "type": "string"
          },
          "tier": {
            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
            "enum": [
              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_drug_drug_interaction_failures",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
            "type": "boolean"
          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "ADCs that failed at any stage.",
      "inputSchema": {
        "properties": {
          "compound": {
            "description": "compound name, ChEMBL ID, or InChIKey",
            "type": "string"
          },
          "limit": {
            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "outcome": {
            "description": "outcome filter (inactive, failed_safety, terminated, …)",
            "type": "string"
          },
          "target": {
            "description": "UniProt accession or gene symbol",
            "type": "string"
          },
          "tier": {
            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
            "enum": [
              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_failed_adcs",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
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            "description": "True when more results exist beyond this page.",
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            "description": "outcome filter (inactive, failed_safety, terminated, …)",
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            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
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            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
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            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
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            "type": "integer"
          },
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            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
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              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [
          "indication"
        ],
        "type": "object"
      },
      "name": "search_indication_history",
      "outputSchema": {
        "properties": {
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            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
            "type": "boolean"
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          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
            "type": "integer"
          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Approaches that failed for a mechanism (by target).",
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        "properties": {
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            "description": "compound name, ChEMBL ID, or InChIKey",
            "type": "string"
          },
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            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
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            "minimum": 1,
            "type": "integer"
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            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
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            "type": "integer"
          },
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            "description": "outcome filter (inactive, failed_safety, terminated, …)",
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          },
          "target": {
            "description": "UniProt accession or gene symbol",
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          },
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            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
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              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_mechanism_failures",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
            "type": "string"
          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
            "type": "boolean"
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          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
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          },
          "returned_count": {
            "description": "Findings returned in this page.",
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          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Oligonucleotide delivery failures.",
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        "properties": {
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            "description": "compound name, ChEMBL ID, or InChIKey",
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            "description": "Maximum number of findings to return (1–100, default 25).",
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            "minimum": 1,
            "type": "integer"
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            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
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            "type": "integer"
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            "description": "outcome filter (inactive, failed_safety, terminated, …)",
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          },
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            "description": "UniProt accession or gene symbol",
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          },
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            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
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              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_oligo_delivery_failures",
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        "properties": {
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            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
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          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
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          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
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          },
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            "description": "Findings returned in this page.",
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          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Vaccine + antimicrobial + antibody failures for a pathogen.",
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        "properties": {
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            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
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            "minimum": 1,
            "type": "integer"
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          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
            "minimum": 0,
            "type": "integer"
          },
          "pathogen": {
            "description": "pathogen name (required)",
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          },
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            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
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              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [
          "pathogen"
        ],
        "type": "object"
      },
      "name": "search_pathogen_history",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
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          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
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              "type": "object"
            },
            "type": "array"
          },
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            "description": "True when more results exist beyond this page.",
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          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
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          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Peptide stability/half-life failures.",
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            "description": "compound name, ChEMBL ID, or InChIKey",
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            "description": "Number of findings to skip before this page, for pagination (default 0).",
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            "description": "outcome filter (inactive, failed_safety, terminated, …)",
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          },
          "target": {
            "description": "UniProt accession or gene symbol",
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          },
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            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
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              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_peptide_stability_issues",
      "outputSchema": {
        "properties": {
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            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
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          },
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            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
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              "type": "object"
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            "type": "array"
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          "has_more": {
            "description": "True when more results exist beyond this page.",
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          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
            "type": "object"
          },
          "returned_count": {
            "description": "Findings returned in this page.",
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        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "PROTAC E3-ligase recruitment / ternary failures.",
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            "description": "compound name, ChEMBL ID, or InChIKey",
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            "description": "Maximum number of findings to return (1–100, default 25).",
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            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
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            "description": "outcome filter (inactive, failed_safety, terminated, …)",
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          },
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            "description": "UniProt accession or gene symbol",
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          },
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              "curated",
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            ],
            "type": "string"
          }
        },
        "required": [],
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      },
      "name": "search_protac_e3_issues",
      "outputSchema": {
        "properties": {
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            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
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            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
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            "description": "True when more results exist beyond this page.",
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            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
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          },
          "returned_count": {
            "description": "Findings returned in this page.",
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        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Clinical/preclinical safety failures across modalities.",
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        "properties": {
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            "description": "compound name, ChEMBL ID, or InChIKey",
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          },
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            "description": "Maximum number of findings to return (1–100, default 25).",
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            "description": "Number of findings to skip before this page, for pagination (default 0).",
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          },
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            "description": "outcome filter (inactive, failed_safety, terminated, …)",
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          },
          "target": {
            "description": "UniProt accession or gene symbol",
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          },
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            "default": "curated",
            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
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              "curated",
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            ],
            "type": "string"
          }
        },
        "required": [],
        "type": "object"
      },
      "name": "search_safety_failures",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
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          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
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            "type": "array"
          },
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            "description": "True when more results exist beyond this page.",
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          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
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          },
          "returned_count": {
            "description": "Findings returned in this page.",
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          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "ALL failed approaches against a target across every modality.",
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        "properties": {
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            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
            "maximum": 100,
            "minimum": 1,
            "type": "integer"
          },
          "offset": {
            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
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          "target": {
            "description": "UniProt accession or gene symbol (required)",
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            "default": "curated",
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              "curated",
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            ],
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          }
        },
        "required": [
          "target"
        ],
        "type": "object"
      },
      "name": "search_target_history",
      "outputSchema": {
        "properties": {
          "coverage_note": {
            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
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          },
          "findings": {
            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
              "type": "object"
            },
            "type": "array"
          },
          "has_more": {
            "description": "True when more results exist beyond this page.",
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          },
          "query_metadata": {
            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
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          },
          "returned_count": {
            "description": "Findings returned in this page.",
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          }
        },
        "required": [
          "query_metadata"
        ],
        "type": "object"
      }
    },
    {
      "description": "Failed vaccine immunogen designs.",
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        "properties": {
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            "description": "compound name, ChEMBL ID, or InChIKey",
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          },
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            "default": 25,
            "description": "Maximum number of findings to return (1–100, default 25).",
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            "minimum": 1,
            "type": "integer"
          },
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            "default": 0,
            "description": "Number of findings to skip before this page, for pagination (default 0).",
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            "type": "integer"
          },
          "outcome": {
            "description": "outcome filter (inactive, failed_safety, terminated, …)",
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          },
          "target": {
            "description": "UniProt accession or gene symbol",
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          },
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            "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).",
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              "curated",
              "all"
            ],
            "type": "string"
          }
        },
        "required": [],
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      },
      "name": "search_vaccine_immunogenicity_failures",
      "outputSchema": {
        "properties": {
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            "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
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          },
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            "description": "Matching negative findings (same shape as the REST /findings endpoint).",
            "items": {
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            "type": "array"
          },
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            "description": "True when more results exist beyond this page.",
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          },
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            "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
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          },
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        },
        "required": [
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        ],
        "type": "object"
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    }
  ]
}

Verify it yourself

curl -s https://api.teppi.xyz/v1/evidence/sha256:2b9bfaeb3ec73c47cbb7036eb6a516e1544d60c593740b235070e0ba7ed46269 | sha256sum